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  11. Usp4 Promotes Ptc Progression By Stabilizing Ldha And Activating The Mapk And Akt Signaling Pathway

USP4 promotes PTC progression by stabilizing LDHA and activating the MAPK and AKT signaling pathway

Chuanxiang Hu1, Wei Zhang1, Yongsheng Jia1

  • 1Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China.

Aging
|October 11, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Ubiquitin-specific protease 4 (USP4) promotes papillary thyroid carcinoma (PTC) growth by stabilizing lactate dehydrogenase A (LDHA). Targeting USP4 may offer a new therapeutic strategy for PTC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Ubiquitin-specific protease 4 (USP4) is implicated in human cancers.
  • The role of USP4 in papillary thyroid carcinoma (PTC) progression is not well understood.

Purpose of the Study:

  • To investigate the function and mechanism of USP4 in PTC.
  • To explore USP4 as a potential therapeutic target for PTC.

Main Methods:

  • Analysis of USP4 expression in PTC tissues.
  • Loss-of-function assays (USP4 silencing).
  • Investigation of USP4 interaction with lactate dehydrogenase A (LDHA).
  • Assessment of MAPK and AKT signaling pathways.

Main Results:

  • USP4 expression is upregulated in PTC tissues and correlates with aggressive features and poor prognosis.
Keywords:
LDHAUSP4papillary thyroid carcinoma

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  • Silencing USP4 inhibits PTC cell proliferation.
  • USP4 stabilizes LDHA protein levels through deubiquitination.
  • USP4 promotes PTC proliferation via modulation of MAPK and AKT pathways.

    • Conclusions:

    • The USP4/LDHA axis is crucial for PTC progression.
    • USP4 modulates MAPK and AKT signaling pathways in PTC.
    • USP4 represents a potential therapeutic target for PTC treatment.