Rich nutrition decreases the concentration of metals in Chaeturichthys stigmatias

Metals play a vital role in living organisms, serving as cofactors for enzymes, structural components of proteins, and participants in signaling pathways. However, the relationship between metal content and nutrient levels in organisms has not been thoroughly elucidated, which is the major barrier to regulate metal levels in organisms. In this study, we investigated the association between muscle metal concentration and external nutritional conditions, as well as intrinsic nutrient requirements in Chaeturichthys stigmatias. The results demonstrated a negative correlation between muscle metal levels and body mass index (BMI). Furthermore, our investigation unveiled a negative correlation between metal levels and zooplankter abundance, as well as a positive correlation with the abundance of underlying phytoplankton and chlorophyll. Moreover, metal levels gradually increased during the development of gonads, particularly in female individuals. As the gonads matured and ovulated, metal levels gradually decreased. The same trends were observed in Mouse erythroleukemia cells (MEL) when different concentrations of FBS were added. Collectively, these findings highlight the inherent connection between metal levels and nutrition, and offer potential guidance for regulating metal homeostasis in organisms, as well as reducing the exposure of organisms to toxic heavy metals in the environment. SYNOPSIS: With an increase in the level of external nutrients and a decrease in intrinsic nutrient requirements, the level of metals in the organism gradually decreases.