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Endocrine disrupting effects on morphological synaptic plasticity.

Attila Zsarnovszky1, Daiana Alymbaeva2, Gergely Jocsak2

  • 1Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, Hungary; Department of Physiology and Animal Health, Agrobiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, H-7400 Kaposvár, Hungary.

Frontiers in Neuroendocrinology
|October 11, 2024
PubMed
Summary

Endocrine disrupting chemicals (EDCs) may impact brain health by altering synaptic plasticity, a key process for neural regulation. Further research is needed to understand these effects on morphological synaptic plasticity (MSP).

Keywords:
AstrogliaEndocrine disrupting chemicalsEstrogenEstrogen receptorNervous systemSynaptic plasticity

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Area of Science:

  • Neuroendocrinology
  • Synaptic Plasticity
  • Toxicology

Background:

  • Homeostasis relies on neural regulation via synaptic function.
  • Synaptic plasticity (SP) adapts synaptic functions, modulated by hormonal circuits.
  • Hormonal regulation is increasingly targeted by endocrine disrupting chemicals (EDCs).

Purpose of the Study:

  • To review the effects of EDCs on morphological synaptic plasticity (MSP).
  • To highlight molecular mechanisms affected by EDCs in SP.
  • To emphasize the need for further neuroendocrinology research in this area.

Main Methods:

  • Literature review of existing studies on EDCs and MSP.
  • Analysis of molecular pathways implicated in EDC-induced alterations of SP.
  • Synthesis of current knowledge on EDC impacts on neuroplasticity.

Main Results:

  • Growing evidence suggests EDCs affect MSP, a form of SP.
  • EDCs can act as agonists or antagonists of endogenous hormones.
  • Specific molecular mechanisms underlying EDC effects on MSP are being identified.

Conclusions:

  • EDCs pose a potential threat to neural regulation by disrupting MSP.
  • Understanding EDC-induced neuroplasticity changes is crucial for public health.
  • More research is essential to elucidate the full impact of EDCs on the neuroendocrine system.