2-Mercaptobenzothiazole-derived vulcanization accelerators in urine samples from Chinese adults

Area of Science:

• Environmental Chemistry
• Toxicology
• Human Biomonitoring

Background:

• 2-mercaptobenzothiazole (2-MBT) and its derivatives (MVAs) are prevalent in household dust, indicating environmental presence.
• Human exposure to MVAs is plausible, yet their occurrence in human urine remains understudied.

Purpose of the Study:

• To comprehensively analyze the presence and levels of 11 different MVAs in urine samples from a general population in Taizhou, China.
• To assess human exposure to these emerging environmental chemicals.

Main Methods:

• Urine samples were collected from 197 individuals in the general population.
• Quantification of 11 MVAs using advanced analytical techniques.
• Statistical analysis to determine prevalence, concentration, and correlations with demographic factors.

Main Results:

• Five MVAs were detected in over 50% of urine samples, confirming widespread human exposure.
• 2-MBT and 2,2'-dithiobisbenzothiazole (MBTS) were the predominant analytes.
• Higher urinary levels of 2-MBT and N-cyclohexyl-2-benzothiazolamine were observed in males.
• Urinary concentrations of 2-MBT and MBTS showed a significant inverse correlation with age.

Conclusions:

• This study provides the first comprehensive characterization of multiple MVAs in human urine.
• The findings demonstrate significant human exposure to these vulcanization accelerators.
• Data are critical for understanding exposure pathways and potential health implications of MVAs.