Amniotic membrane graft for persistent macular hole following retinal detachment repair in Knobloch syndrome

We report the case of a 7-year-old girl with Knobloch syndrome who presented with retinal detachment due to a macular hole, which was treated with vitrectomy and silicone oil tamponade. The macular hole persisted, and recurrent silicone oil emulsification required exchanges, with two subsequent vitrectomies. Finally, an amniotic membrane graft was used to seal the macular hole in an effort to avoid silicone oil dependence for retinal attachment. The macular hole was successfully closed, and the retina remained attached 6 months after surgery.