Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Temporal regulation of human reactive astrocytes reveals their capacity for antigen presentation.

Neuron·2026

Same author

Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.

Cell systems·2026

Same author

Tissue-specific immune and MAPK signatures in models of reduced Progranulin and Western diet.

Neurobiology of disease·2026

Same author

The gut microbiome promotes detoxification responses to an environmental toxicant.

bioRxiv : the preprint server for biology·2025

Same author

The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract.

Toxicological sciences : an official journal of the Society of Toxicology·2025

Same author

Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jun 10, 2025

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

Microbiome-based therapeutics for Parkinson's disease.

Adam M Hamilton¹, Ian N Krout¹, Alexandria C White¹

¹Department of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics

|October 11, 2024

Summary

Parkinson's disease (PD) is linked to gut microbiome changes. Clinical studies are exploring microbiome therapies like fecal transplants, prebiotics, and probiotics to potentially treat PD symptoms and slow disease progression.

Keywords:

Gut-brain axis Microbiome Parkinson's disease Therapeutics

More Related Videos

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Related Experiment Videos

Last Updated: Jun 10, 2025

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Area of Science:

Neuroscience
Microbiology
Gastroenterology

Background:

Gut microbiome dysregulation is increasingly recognized in Parkinson's disease (PD).
This dysregulation may directly or indirectly influence PD pathology.
Experimental models highlight microbiome-dependent impacts on PD.

Purpose of the Study:

To review recent and ongoing clinical studies on microbiome-targeted therapies for Parkinson's disease.
To examine the potential of microbiome restoration for limiting PD severity and progression.

Main Methods:

Review of clinical trials investigating microbiome-targeted interventions.
Analysis of studies using fecal microbiome transplants, prebiotic interventions, and probiotic supplementation.

Main Results:

Emerging evidence suggests microbiome-targeted therapies are viable for augmenting the gut microbiome in PD patients.
These interventions show potential for limiting PD symptoms.

Conclusions:

The gut microbiome plays a significant role in Parkinson's disease.
Continued research and clinical translation are crucial to identify key microbial factors and optimize microbiome-based therapies for PD.