Related Experiment Video
Updated: Jun 10, 2025
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
478
Targeted metabolomic profiling of acute ST-segment elevation myocardial infarction.
Sergey S Markin1, E A Ponomarenko2, Yu A Romashova2
1Institute of Biomedical Chemistry, Moscow, 119121, Russia. phospholipovit@ibmc.msk.ru.
Scientific Reports
|October 11, 2024
Summary
This study reveals altered metabolite levels in ST-segment elevation myocardial infarction (STEMI) patients, identifying key metabolic pathways and ratios for improved diagnosis and understanding of heart attack pathogenesis.
Area of Science:
- Cardiovascular Medicine
- Metabolomics
- Biochemistry
Background:
- Myocardial infarction (MI) is a leading global cause of death.
- Metabolomics offers potential insights into the complex pathogenesis of ST-segment elevation myocardial infarction (STEMI).
Purpose of the Study:
- To conduct targeted metabolomic profiling in STEMI patients.
- To identify significantly altered metabolites and metabolite ratios associated with STEMI pathogenesis.
- To explore the role of tryptophan metabolism in STEMI.
Main Methods:
- Targeted metabolomic profiling of 87 endogenous metabolites in plasma.
- Analysis of 195 subjects: 68 STEMI patients, 84 stable angina pectoris (SAP) patients, and 43 non-cardiovascular disease (non-CVD) controls.
- Machine learning and weighted correlation network analysis were employed.
Main Results:
- Identified 36 significantly altered metabolites in STEMI patients, including amino acids, acylcarnitines, and NO-urea cycle metabolites.
- Observed significant changes in tryptophan metabolism, with increased anthranilic acid and tryptophol, and decreased xanthurenic acid and 3-OH-kynurenine.
- Discovered 22 significantly altered metabolite ratios, with seven common between STEMI vs. non-CVD and STEMI vs. SAP comparisons.
Conclusions:
- Targeted metabolomic profiling provides novel insights into STEMI pathogenesis.
- Specific metabolite ratios, such as anthranilic acid to aspartic acid and GSG, may serve as diagnostic biomarkers.
- Understanding metabolic alterations in STEMI can inform future diagnostic and therapeutic strategies.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic studies
3
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
3
01:30Acute Coronary SyndromeI: Introduction
3
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
3
01:19Acute Coronary Syndrome II: Pathophysiology and clinical manifestations
3
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
3
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
105
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
105
01:27Myocarditis II: Clinical features and Diagnostic Tests
2
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
2