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Related Experiment Video

Updated: Jun 10, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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3D Polymeric Lattice Microstructure-Based Microneedle Array for Transdermal Electrochemical Biosensing.

Muamer Dervisevic1,2, Jann Harberts1,2, Raquel Sánchez-Salcedo1,2

  • 1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.

Advanced Materials (Deerfield Beach, Fla.)
|October 12, 2024
PubMed
Summary

This study introduces a novel 3D printing and soft lithography method for creating complex microneedle arrays (MNAs). This advanced fabrication technique enables cost-effective, time-saving production of MNAs for improved biosensing applications.

Keywords:
biosensorsglucoseinsulinmicrofabricationmicroneedlestwo‐photon lithography

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Last Updated: Jun 10, 2025

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Microneedle arrays (MNAs) are crucial for minimally invasive diagnostics and personalized healthcare monitoring.
  • Current fabrication methods limit the complexity and clinical applicability of MNAs.
  • There is a need for advanced manufacturing techniques to create sophisticated MNA devices.

Purpose of the Study:

  • To develop a cost-effective and time-saving method for fabricating complex microneedle arrays (MNAs).
  • To create a novel platform for electrochemical biosensing using advanced MNAs.
  • To demonstrate the potential of the fabricated MNAs for detecting clinically relevant biomarkers.

Main Methods:

  • Utilized two-photon polymerization 3D printing to create intricate master structures.
  • Employed soft lithography to replicate these structures into polymeric substrates, forming polymeric lattice (PL) membranes.
  • Transferred PL membranes onto gold-coated microneedles for electrochemical biosensing.

Main Results:

  • Successfully fabricated complex MNAs with enhanced surface properties.
  • Demonstrated excellent electrochemical performance of the MNA platform for biosensing.
  • Achieved a dynamic linear range suitable for detecting glucose and insulin biomarkers in relevant concentrations.

Conclusions:

  • The combined 3D printing and soft lithography approach offers an efficient way to produce complex MNAs.
  • This technology holds significant potential for developing next-generation microneedle devices for clinical applications.
  • The developed MNA platform shows promise for personalized healthcare monitoring and diagnostics.