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Exploring the efficacy and tolerability of two-injection start regimen of long-acting aripiprazole: A descriptive

Ibrahim Sungur1,2, Kaan Keskin1,2, Elif Özge Aktaş1,2

  • 1Department of Psychiatry, Ege University, Izmir, Turkey.

Neuropsychopharmacology Reports
|October 12, 2024
PubMed

Insights

Aripiprazole long-acting injections can effectively treat manic episodes in bipolar disorder patients. This study found a double injection start regimen safe and well-tolerated, potentially reducing hospital stays.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Bipolar disorder is a leading cause of disability worldwide.
  • Manic episodes often necessitate lengthy hospitalizations, impacting patient freedom.
  • Safer, effective treatments to shorten hospital stays for mania are crucial.

Observation:

  • Aripiprazole long-acting injection is approved for bipolar mania and maintenance.
  • A simplified starting strategy using two injections and an oral dose is approved for schizophrenia.
  • This regimen's safety and efficacy in bipolar disorder were previously unreported.

Findings:

  • A case series of eight patients with manic episodes and psychotic features was studied.
  • The double injection start regimen demonstrated effectiveness in managing manic symptoms.
  • No severe adverse events were observed, indicating good tolerability.

Implications:

  • This double injection start regimen shows promise for treating acute manic episodes in bipolar disorder.
  • The findings suggest a potential strategy to reduce hospitalization duration.
  • Further research with larger samples is warranted to confirm these preliminary results.
Keywords:
antipsychoticsaripiprazolebipolar disorder

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