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Stable Porous Organic Cage Nanocapsules for pH-Responsive Anticancer Drug Delivery for Precise Tumor Therapy

Yanping Deng1, Zhenhong Du1, Shunfu Du2,3

  • 1Fujian Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China.

ACS Applied Bio Materials
|October 12, 2024
PubMed

Insights

Porous organic cages (POCs) were used as nanocarriers for paclitaxel (PTX) drug delivery, showing enhanced anticancer efficacy and bioavailability in preclinical models. This novel application offers a promising approach for targeted cancer therapy.

Area of Science:

  • Biomedical research
  • Materials science
  • Nanotechnology
  • Drug delivery systems

Background:

  • Developing stimuli-responsive nanocarriers for targeted drug delivery and precision medicine is a key research area.
  • Existing nanocarrier systems face challenges in achieving high drug payloads and controlled release.
  • Porous organic cages (POCs) have emerged as potential candidates for drug encapsulation and delivery.

Purpose of the Study:

  • To investigate the use of porous organic cages (POCs) as nanocarriers for paclitaxel (PTX) in cancer therapy.
  • To evaluate the stability, drug loading, release kinetics, and in vivo performance of PTX-loaded POC nanocapsules.

Main Methods:

  • Synthesis of POC-based nanocapsules (PTX@POC@RH40) by grafting Polyoxyl 40 hydrogenated castor oil (RH40) onto POCs.
  • Assessment of PTX encapsulation efficiency, nanocapsule stability, and pH-responsive drug release.
  • Evaluation of PTX bioavailability and anticancer efficacy in rat and 4T1 breast cancer mouse models.

Main Results:

  • PTX@POC@RH40 nanocapsules achieved over 98% PTX encapsulation efficiency and exhibited excellent stability.
  • Nanocapsules demonstrated pH-responsive release at acidic conditions (pH 5.5) and sustained release at physiological pH (7.4).
  • Intravenous administration resulted in a 3.5-fold increase in PTX bioavailability and enhanced tumor inhibition with reduced toxicity in vivo.

Conclusions:

  • POC-based nanocapsules are effective carriers for paclitaxel, improving its bioavailability and therapeutic efficacy.
  • The developed nanocarriers show promising stimuli-responsive and sustained release properties for cancer therapy.
  • POCs represent a viable platform for developing advanced nanodrug delivery systems for precision medicine applications.
Keywords:
nanocarrier drug deliverypH-responsive deliverypaclitaxelporous organic cagestumor therapy

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