A paper-based organic electrochemical transistor array with a simplified configuration for simultaneous multi-ion...

Area of Science:

• Electrochemistry
• Sensor Technology
• Analytical Chemistry

Background:

• Organic electrochemical transistors (OECTs) offer high amplification and robust performance for analytical applications.
• Existing analytical methods can be enhanced by versatile transistor-based sensing platforms.
• The development of multi-analyte sensors is crucial for complex sample analysis.

Purpose of the Study:

• To develop a compact multi-analyte transistor array with high analytical performance.
• To create highly sensitive and selective ion-selective organic electrochemical transistors (IS-OECTs).
• To demonstrate simultaneous detection and quantification of ions in human saliva using the developed sensor array.

Main Methods:

• Fabrication of ion-selective organic electrochemical transistors (IS-OECTs) using thick-film technology and optimized ion-selective membranes.
• Simplification of the sensing system with individual power supplies and a single gate electrode per OECT.
• Integration of the IS-OECT array with multivariate models for data analysis.
• Validation of results against established reference techniques.

Main Results:

• The developed IS-OECTs exhibit high sensitivity and selectivity.
• The compact multi-analyte array demonstrates outstanding analytical performance.
• Simultaneous detection and quantification of sodium, potassium, and ammonium ions in human saliva were achieved.
• Results were validated against reference methods, showing promising accuracy.

Conclusions:

• The proposed IS-OECT array offers a versatile and effective platform for multi-analyte sensing.
• The simplified system design enhances practicality and usability.
• This technology holds significant potential for point-of-care diagnostics and environmental monitoring.
• The developed sensing array confirms its usefulness for analyzing complex biological samples like saliva.