Peptides as innovative strategies to combat drug resistance in cancer therapy

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Henry O Lamb1, Aurélie H Benfield1, Sónia Troeira Henriques2

  • 1School of Biomedical Sciences, Queensland University of Technology (QUT), Translational Research Institute, Brisbane, QLD 4102, Australia.

Drug Discovery Today
|October 12, 2024
PubMed

Insights

Peptide-based therapies show promise in overcoming cancer drug resistance. These innovative treatments can target tumors, enhance drug delivery, and inhibit resistance mechanisms, improving patient outcomes.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Drug resistance is a primary reason for cancer treatment failure.
  • Developing novel therapeutic strategies is crucial to improve patient outcomes.
  • Peptide-based therapies are emerging as a potential solution to combat cancer drug resistance.

Purpose of the Study:

  • To review the potential of peptide-based therapies in overcoming cancer drug resistance.
  • To explore the unique strategies and mechanisms employed by peptides in cancer treatment.
  • To highlight how peptides can address both intrinsic and adaptive resistance to various cancer therapies.

Main Methods:

  • Literature review of existing research on peptide-based cancer therapies.
  • Analysis of peptide mechanisms targeting tumor cells and resistance pathways.
  • Examination of peptide applications in overcoming resistance to chemotherapy, targeted therapies, and biologics.

Main Results:

  • Peptides can selectively target tumor cells, minimizing off-target effects.
  • Peptides can facilitate the delivery of drugs into cancer cells, enhancing efficacy.
  • Peptides can inhibit key intracellular proteins that drive cancer progression and resistance.

Conclusions:

  • Peptide-based therapies represent a promising strategy to overcome cancer drug resistance.
  • These therapies offer a versatile approach to combatting resistance to chemotherapy, targeted therapies, and biologics.
  • Further research and development in peptide therapeutics could significantly improve cancer treatment outcomes.
Keywords:
anticancer therapiescyclic peptidesdrug resistancemembrane-active peptidespeptide–drug conjugateprotein–protein interactions

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