Impact of sarcopenia and muscle strength on postoperative complication risk following pancreatic resection
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View abstract on PubMed
Summary
This summary is machine-generated.Sarcopenia, identified using international criteria, increases major postoperative complications in pancreatic surgery patients. Regional criteria show higher prevalence but no increased risk. Muscle strength assessment methods vary in outcome prediction.
Area Of Science
- Gerontology
- Surgical Oncology
- Clinical Nutrition
Background
- Sarcopenia is linked to adverse outcomes in cancer patients undergoing surgery.
- Standardized diagnostic criteria and muscle strength assessments are lacking for clinical use.
- Pancreatic surgery carries significant postoperative risks, necessitating better patient risk stratification.
Purpose Of The Study
- To evaluate the impact of sarcopenia, defined by international and regional cut-off points, on postoperative complications.
- To compare different methods of assessing skeletal muscle and muscle strength in predicting surgical outcomes.
- To clarify the association between sarcopenia and major complications following pancreatic resection.
Main Methods
- Prospective observational study of 134 patients undergoing pancreatic resection.
- Body composition assessed by DXA and CT; sarcopenia classified using EWGSOP and Danish normative criteria.
- Muscle strength evaluated by handgrip, leg extensor power, and sit-to-stand tests; complications graded by Clavien-Dindo and ACS-NSQIP.
Main Results
- Sarcopenia by international CT criteria (7%) associated with increased major complications (RR 2.14).
- Sarcopenia by international DXA criteria (3%) showed all patients experiencing major complications.
- Regional CT criteria (13%) and DXA criteria (7%) did not associate with increased major complications.
- Handgrip strength showed a consistent association with postoperative complications across methods.
Conclusions
- Sarcopenia, defined by EWGSOP criteria and international cut-offs, predicts increased postoperative complications after pancreatic resection.
- Regional cut-off points yield higher sarcopenia prevalence but do not correlate with increased complication risk.
- Variability in muscle strength assessment methods significantly impacts prevalence estimates and outcome associations.
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