Racial disparities in thyroid cancer outcomes: A systematic review
View abstract on PubMed
Summary
This summary is machine-generated.Racial disparities in thyroid cancer outcomes show non-White patients may face higher risks of advanced disease at diagnosis. Further research with detailed racial data is crucial for understanding and addressing these disparities.
Area Of Science
- Oncology
- Surgical Outcomes
- Health Disparities
Background
- Racial disparities in surgical outcomes are documented, yet specific trends in thyroid cancer are understudied.
- This systematic review aims to clarify the impact of race on thyroid cancer outcomes.
Purpose Of The Study
- To systematically review existing literature on thyroid cancer outcomes and analyze the influence of race.
- To identify potential racial disparities in the presentation and outcomes of differentiated thyroid cancer.
Main Methods
- A comprehensive systematic search of academic databases was conducted following PRISMA guidelines.
- Included studies focused on adult differentiated thyroid cancer in the US, reporting race, with data from 7,221 patients across 12 studies.
- Chi-square statistics were used to analyze compiled data on outcomes by race.
Main Results
- Non-White patients, particularly Black and Hispanic individuals, showed a higher incidence of extrathyroidal extension compared to White patients.
- Thyroid cancer stage T1a and recurrence rates were similar across racial groups.
- Race was infrequently reported in the analyzed thyroid cancer outcome studies.
Conclusions
- Non-White patients may have an increased risk of presenting with more advanced local thyroid cancer.
- Limited reporting of race in thyroid cancer studies hinders a comprehensive understanding of disparities.
- Granular data on race is essential for developing strategies to mitigate racial disparities in thyroid cancer outcomes.
Related Concept Videos
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

