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Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prognostic Value Of Systemic Immune-inflammation Index And Systemic Inflammation Response Index For Oral Cancers: A Systematic Review And Meta-analysis.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prognostic Value Of Systemic Immune-inflammation Index And Systemic Inflammation Response Index For Oral Cancers: A Systematic Review And Meta-analysis.

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Prognostic value of systemic immune-inflammation index and systemic inflammation response index for oral cancers: A systematic review and meta-analysis.

S Yang1, C Fei

  • 1Department of Stomatology The second affiliated hospital of Jiaxing university 1518 Huancheng North Road, Jianshe Street Nanhu District, Jiaxing City, Zhejiang Province, China Callit9596@163.com.

Medicina Oral, Patologia Oral Y Cirugia Bucal
|October 13, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

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High systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) scores predict poorer outcomes in oral cancer patients. These inflammatory markers are associated with reduced overall survival and disease-free survival.

Area of Science:

  • Oncology
  • Immunology
  • Biomarkers

Background:

  • The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are established prognosticators in various cancers.
  • Their predictive value in oral cancers remains largely unexplored.

Purpose of the Study:

  • To systematically evaluate the prognostic capability of SII and SIRI for overall survival (OS) and disease-free survival (DFS) in oral cancer patients.

Main Methods:

  • A comprehensive literature search was conducted across Embase, PubMed, Web of Science, and Scopus.
  • Included studies published up to May 25, 2024, that reported OS or DFS based on SII or SIRI in oral cancer cohorts.

Main Results:

  • Seventeen studies (14 on SII, 3 on SIRI) met the eligibility criteria.
  • Elevated pretreatment SII scores significantly correlated with poorer OS (HR: 1.62) and DFS (HR: 1.62) in oral cancer.
  • High SIRI was also associated with worse OS (HR: 1.60).
  • Sensitivity analyses confirmed these findings, though subgroup analyses yielded mixed results.

    • Conclusions:

    • Both SII and SIRI demonstrate potential as prognostic biomarkers for oral cancers.
    • Higher SII and SIRI scores are linked to worse overall survival, and higher SII also predicts worse disease-free survival.