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[A comparison of locally acting antiseptics, increasingly recommended as an alternative to antibiotics]

Stefani Maihoub1, Magdolna Krasznai1, András Molnár1

  • 11 Semmelweis Egyetem, Általános Orvostudományi Kar, Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika Budapest, Szigony u. 36., 1083 Magyarország.

Orvosi Hetilap
|October 13, 2024
PubMed

Insights

Antimicrobial resistance necessitates exploring topical antiseptics. This review examines antiseptic properties, efficacy, and challenges, highlighting their potential role in clinical practice.

Area of Science:

  • Clinical Microbiology
  • Dermatology
  • Infectious Diseases

Background:

  • Antibiotic overuse has driven antimicrobial resistance, increasing the need for alternative disinfectants.
  • Topical antiseptics offer a promising alternative due to their broad-spectrum action and lower resistance potential.

Purpose of the Study:

  • To review the challenges and antimicrobial properties of key topical antiseptics.
  • To evaluate the efficacy, resistance potential, and safety profiles of selected antiseptics.

Main Methods:

  • Literature review of current research on topical antiseptics.
  • Comparative analysis of octenidine dihydrochloride, povidone-iodine, hydrogen peroxide, chlorhexidine, and isopropyl alcohol.

Main Results:

  • Antiseptics exhibit varied antimicrobial efficacy and resistance profiles.
  • Challenges include tolerability, inactivation by organic matter, and potential side effects.
  • Wound-healing properties and skin compatibility differ among agents.

Conclusions:

  • Topical antiseptics are crucial in managing antimicrobial resistance.
  • Careful selection based on efficacy, safety, and specific clinical context is essential.
  • Further research into optimizing antiseptic use and minimizing side effects is warranted.
Keywords:
chlorhexidinehidrogén-peroxidhydrogen peroxideisopropyl alcoholizopropil-alkoholklórhexidinoctenidine dihydrochlorideoktenidin-dihidrokloridpovidon-jódpovidone-iodine

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