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The T-cell receptor/T3 complex.

C Terhorst, P van den Elsen

    The Year in Immunology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    The T-cell receptor (TCR) and T3 complex mediate T-cell activation. Researchers propose the T3-epsilon chain may function as a calcium gate, crucial for signal transduction.

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    Area of Science:

    • Immunology
    • Molecular Biology
    • Cell Biology

    Background:

    • The T-cell receptor/T3 complex is vital for human thymus-derived lymphocyte function.
    • This complex comprises variable alpha/beta chains and invariant gamma, delta, epsilon chains.

    Purpose of the Study:

    • To elucidate the functional roles of T-cell receptor/T3 complex components.
    • To investigate the mechanism of signal transduction initiated by T-cell activation.

    Main Methods:

    • Isolation of genes encoding T-cell receptor alpha, beta, and delta chains.
    • Functional studies analyzing T-cell activation and signal transduction pathways.

    Main Results:

    • A division of labor exists between the T-cell receptor (TCR) alpha/beta chains and the T3-gamma, -delta, -epsilon chains.

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  • The TCR alpha/beta chains recognize antigen and MHC, while the T3 complex transduces the activation signal.
  • Calcium ion (Ca2+) influx is hypothesized to be pivotal in signal transduction.

    • Conclusions:

    • The T3 complex is essential for initiating T-cell responses upon ligand binding.
    • The T3-epsilon chain is postulated to function as a calcium gate, regulating Ca2+ influx.