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"Pseudolysogenization" by RNA phage Q beta.

I Watanabe, T Sakurai, K Furuse

    Microbiology and Immunology
    |January 1, 1979
    PubMed
    Summary
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    Researchers discovered pseudolysogenic bacteria, a stable lysogenic-like state in RNA phage Q beta (Q beta am 205) and its host. These bacteria maintain phage RNA genomes and replicate them during cell division.

    Area of Science:

    • Microbiology
    • Virology
    • Molecular Biology

    Background:

    • Lysogeny is a stable state where bacteriophages integrate into the host genome.
    • Bacteriophage Q beta (Q beta) is an RNA phage with a nonpermissive host, BE110.

    Purpose of the Study:

    • To isolate and characterize stable lysogenic-like bacteria from a Q beta and BE110 interaction.
    • To investigate the replication and distribution of phage RNA genomes in nonpermissive hosts.

    Main Methods:

    • Isolation of bacteria from a lysogenic state established between Q beta am 205 and BE110.
    • Culturing bacteria in liquid medium with anti-Q beta serum.
    • Quantification of intracellular mature phages and RNA genomes.

    Main Results:

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    • Stable lysogenic-like bacteria, termed pseudolysogenic, were isolated.
    • These bacteria showed low levels of intracellular mature phages (<10(-3) PFU/cell).
    • Pseudolysogenic bacteria maintained Q beta am 205 RNA genomes (approx. 10(2) strands/cell) and replicated them during cell division.

    Conclusions:

    • Pseudolysogenic bacteria represent a stable phage-host interaction in nonpermissive conditions.
    • The phage RNA genomes can replicate and be stably inherited by daughter cells.
    • This state confers immunity-like response against homologous phage infection.