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Clinical and pathological features of cerebrospinal meningitis caused by Pantoea agglomerans : a case report

Honghao Li1, Jing Yu2, Ziling Zeng3

  • 1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan City, China.

BMC Infectious Diseases
|October 13, 2024
PubMed
Abstract

Insights

Pantoea agglomerans can cause meningitis in healthy adults, even with mild initial symptoms. Early detection through cerebrospinal fluid analysis and prompt antibiotic treatment are crucial for recovery.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Microbiology

Background:

  • Pantoea agglomerans, an opportunistic pathogen, typically infects immunocompromised individuals.
  • Central nervous system (CNS) infections by P. agglomerans are rare in healthy adults.

Observation:

  • A case of P. agglomerans cerebrospinal meningitis in a 49-year-old female with no history of trauma.
  • Patient presented with fever, headache, muscle pain, and neurological deficits.
  • Cerebrospinal fluid analysis showed elevated white blood cells, low glucose, and high protein levels.

Findings:

  • Metagenomic sequencing confirmed P. agglomerans in cerebrospinal fluid.
  • Spinal MRI revealed meningeal thickening and enhancement.
  • Pathology showed inflammation, necrosis, and calcification of the dura mater.

Implications:

  • P. agglomerans meningitis can present with subtle symptoms in adults.
  • Individuals in agricultural/forestry work are at higher risk.
  • Prompt antibiotic therapy is effective for P. agglomerans CNS infections.
Keywords:
Pantoea agglomerans, central nervous systemCerebrospinal meningitisMPO-ANCAMetagenomic next-generation sequencing

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