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Updated: Jun 10, 2025

Sample Preparation for Probe Electrospray Ionization Mass Spectrometry
Published on: February 19, 2020
B4C-Assisted Paper Spray Ionization Mass Spectrometry
Dimei Hu1, Lulu Yu1, Zijian Wei1
1Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, China.
Abstract:
A novel inorganic nonmetallic material boron carbide (B4C) was applied in paper spray ionization to analyze organic molecules in both negative and positive modes. The utilization of B4C has led to a notable enhancement in signal responses for various molecules, including bisphenols and drugs, by approximately two to four times. The limit of detection (LOD) of bisphenol AF and nilotinib standard solutions can reach 1 and 0.5 μg/mL, respectively. Moreover, linear relationships for bisphenol AF was established within the concentration range of 1-100 μg/mL, exhibiting strong correlation coefficients. Recovery experiments for BPAF in water samples from the inlet and outlet of a sewage treatment plant, conducted without any pretreatment, achieved a maximum recovery rate of 98.8% and an RSD below 9.78%.
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