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Updated: Jun 26, 2026

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
Published on: February 26, 2018
Lighting up Mycobacteria with membrane-targeting peptides
Zainab S Alghamdi1,2, Richa Sharma1, Nancy Kiruthiga3
1School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ Edinburgh, UK.
Abstract:
We report a series of fluorescent probes based on mycobacteria membrane-associated disruption peptide, containing either L- or D-amino acids which were originally designed to kill Mycobacterium tuberculosis via membrane disruption. These peptides were decorated with "always on" and environmentally sensitive fluorophores and showed the rapid and efficient labelling of Mycobacterium smegmatis, with labelling of Mycobacterium tuberculosis demonstrated by two of the probes.
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