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Updated: Jun 10, 2025

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
Haemodynamic monitoring after paediatric cardiac surgery using echocardiography and PiCCO
Fredrik Pernbro1,2, Håkan Wåhlander3,4, Birgitta Romlin1,2
1Department of Paediatric Anaesthesiology and Intensive Care, University of Gothenburg, Institute of Clinical Sciences, Gothenburg, Sweden.
Insights
Cardiac output monitoring after pediatric heart surgery showed good average agreement between echocardiography and transpulmonary thermodilution (PiCCO™). However, wide result variations question their interchangeable clinical use.
Area of Science:
- Pediatric Cardiology
- Critical Care Medicine
- Medical Device Technology
Background:
- Hemodynamic instability is frequent post-pediatric congenital heart defect (CHD) repair.
- Cardiac output monitoring, alongside traditional parameters, can enhance postoperative care.
- Echocardiography and transpulmonary thermodilution are primary methods for infant cardiac output measurement.
Purpose of the Study:
- To compare cardiac output measurements from echocardiography and transpulmonary thermodilution (PiCCO™) post-pediatric cardiac surgery.
- To evaluate the agreement and clinical applicability of these two cardiac output monitoring techniques.
Main Methods:
- Prospective, observational study involving 40 children undergoing elective septal defect repair.
- Simultaneous cardiac output measurements using echocardiography and PiCCO™ at 18 hours post-surgery.
- Inclusion criteria: elective ventricular septal defect or atrio-ventricular septal defect repair via cardiopulmonary bypass.
Main Results:
- PiCCO™ reported a mean cardiac output 3.0% higher than echocardiography, a difference not statistically significant.
- The 95% limits of agreement ranged widely from -50.0% to 82.6%.
- No statistically significant difference was found between the two methods on average.
Conclusions:
- Echocardiography and PiCCO™ demonstrate good average agreement for cardiac output measurement in pediatric post-cardiac surgery patients.
- The substantial variability in individual measurements raises concerns about the interchangeability of these methods in clinical practice.
- Further research may be needed to refine the use of these techniques for reliable, individualized patient management.
Background:
Haemodynamic instability is common after surgical repair of CHDs in infants and children. Monitoring cardiac output in addition to traditional circulation parameters could improve the postoperative care of these patients. Echocardiography and transpulmonary thermodilution are the two most common methods for measuring cardiac output in infants.
Objectives:
To compare the results of cardiac output measurements using echocardiography and a transpulmonary thermodilution setup after paediatric cardiac surgery.
Methods:
Forty children, scheduled for elective repair of a ventricular septal defect or of an atrio-ventricular septal defect using cardiopulmonary bypass, were enrolled in this prospective, observational study. Cardiac output was simultaneously measured using echocardiography and a commercially available transpulmonary thermodilution method (PiCCO™) at 18 h after the end of surgery.
Results:
At 18 h after surgery, PiCCO™ gave a mean of 3.0% higher cardiac output than echocardiography. This difference was not statistically significant. 95% of the observations fell within -50.0 to 82.6%.
Conclusion:
The methods were found to have a good agreement on average, with no statistically significant difference between them. However, the spread of the results was large. It is questionable whether the methods can be used interchangeably in clinical practice.
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