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Comparative analysis of clinical profile, laboratory profile and outcome in COVID-19 patients with and without
B Sindhu Malini1, Yoganathan Chidambaram1, C P Clement Jenil Dhas1
1Department of General Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Insights
Hypothyroidism does not worsen COVID-19 severity. This study found no significant differences in symptoms, lab results, or mortality between COVID-19 patients with and without hypothyroidism.
Area of Science:
- Endocrinology
- Infectious Diseases
- Pulmonology
Background:
- Thyroid status may influence Coronavirus disease 2019 (COVID-19) progression.
- Understanding the clinical profile of COVID-19 patients with hypothyroidism is crucial.
Purpose of the Study:
- To determine the clinical profile of COVID-19 patients with hypothyroidism.
- To compare COVID-19 patients with and without hypothyroidism.
Main Methods:
- Retrospective observational study.
- Included 234 patients (117 with hypothyroidism, 117 without).
- Collected data on demographics, symptoms, CT severity, lab values (IL-6, D-dimer), and outcomes.
Main Results:
- Hypothyroidism group had higher incidence of fever, loose stool, and myalgia.
- No significant differences in COVID-19 severity, laboratory values (D-dimer, IL-6), or mortality.
- Both groups reported four mortalities.
Conclusions:
- Hypothyroidism status is not associated with increased COVID-19 severity.
- No significant impact on clinical symptoms, laboratory derangements, or mortality observed.
Objectives:
Previous studies suggest that patients' thyroid status might directly impact the course of Coronavirus disease 2019 (COVID-19). The objective of the study was to determine the clinical profile of COVID-19 patients with hypothyroidism and compare it with that of COVID-19 patients without hypothyroidism.
Design:
Retrospective observational study.
Setting:
The study was conducted in a tertiary healthcare centre in Tamil Nadu between May and June 2021.
Participants:
The study included 117 patients admitted with hypothyroidism and COVID-19 as well as 117 age and Gender matched COVID-19 patients without hypothyroidism.
Main Outcome Measures:
Data regarding the demography, comorbidities, presenting symptoms, method of diagnosis of COVID-19, computed tomography (CT) severity score, Interleukin 6 (IL-6), D-dimer, oxygen requirement, number of days in hospital and outcome were collected for both groups. Data analysis was conducted, and p<0.05 was considered statistically significant.
Results:
The study comprised 234 patients over two months, from May to June 2021. Distribution of presenting symptoms showed that the hypothyroidism group presented with a higher incidence of fever (66.67%), loose stool (18.80%) and myalgia (7.69%). Results show that RTPCR+, O2 Requirement, death, D-dimer, IL-6, number of days admitted as well as CT-severity did not show any statistically significant differences (p>0.05) between both groups. The outcomes also showed that both groups reported four mortalities.
Conclusions:
The results of the study help conclude that the hypothyroidism status of a COVID-19 patient is not associated with higher severity of clinical symptoms, deranged laboratory values as well as mortality.
Funding:
None declared.
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