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Updated: Jun 10, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Inhibition of the SARS-CoV-2 Non-structural Protein 5 (NSP5) Protease by Nitrosocarbonyl-Bases Small Molecules
Marco Leusciatti1,2, Beatrice Macchi3, Francesca Marino-Merlo4
1Department of Chemistry, INSTM Research Unit of Pavia; University of Pavia, Viale Taramelli 10-12, Pavia 27100, Italy.
Abstract:
In the present work, we have designed and synthesized potential NSP5 protease allosteric inhibitors exploiting both docking and molecular dynamic data on SARS-CoV-2. The chemical protocols were developed on the basis of 1,3-dipolar cycloaddition reactions as well as the chemistry of nitrosocarbonyl intermediates. Computational studies were first conducted for determining the best candidate for SARS-CoV-2 NSP5 protease inhibition. Selected compounds were submitted to biological tests, showing low cytotoxicity and moderate activity.
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