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Updated: Jun 10, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
Gut Microbiota in Primary Osteoporosis: a Systematic Review
Jiangxun Ji1,2,3, Feihong Cai1,2,3, Chunchun Yuan1,2,3
1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032 China.
Abstract:
The link between gut microbiota (GM) and primary osteoporosis has garnered substantial attention. In this study, we conducted a systematic review encompassing 10 studies that employed high-throughput sequencing methodologies. Notably, the taxonomic profiles exhibited pronounced heterogeneity across reviewed studies. A combined analysis of mechanistical studies screened out potential targets for osteoporosis prevention and treatment. We appraised the limitations in previous studies, and proposed suggestions for optimizing sequencing techniques and experimental designs. Larger-size longitudinal cohorts based on multi-omics and extended phenotypes are recommended to comprehensively characterize the involvement of GM in the pathogenesis of osteoporosis.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s43657-024-00164-y.
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