Related Experiment Video

Updated: Jun 10, 2025

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
10:01

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Published on: March 12, 2018

10.8K

Comparison of efficacy and safety between loading-dose atorvastatin and rosuvastatin in cerebral infarction

Yanchao Li1, Di Zhang1, Shuang Liu2

  • 1Department of Clinical Pharmacy, The Third Affiliated Hospital of Qiqihar Medical University No. 3, Taishun Street, Tiefeng District, Qiqihar 161000, Heilongjiang, China.

American Journal of Translational Research
|October 14, 2024
PubMed

Insights

Loading-dose statins improve clinical efficacy for cerebral infarction (CI). Rosuvastatin offers better lipid control than atorvastatin, with similar safety profiles in CI patients.

Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Background:

  • Cerebral infarction (CI) poses a significant health challenge.
  • Statins are crucial for managing CI, but optimal dosing strategies require investigation.

Purpose of the Study:

  • To compare the efficacy and safety of loading-dose atorvastatin versus rosuvastatin in treating cerebral infarction (CI).

Main Methods:

  • A retrospective analysis of 151 CI patients was conducted.
  • Patients were divided into four groups: conventional atorvastatin, loading-dose atorvastatin, conventional rosuvastatin, and loading-dose rosuvastatin.
  • Outcomes included NIHSS scores, clinical efficacy, lipid profiles, liver function, inflammation, myocardial indices, and adverse reactions.

Main Results:

  • Loading-dose statins significantly reduced NIHSS scores more than conventional doses.
  • Both loading-dose atorvastatin and rosuvastatin showed high clinical efficacy, with no significant difference between them.
  • Loading-dose rosuvastatin demonstrated superior blood lipid control and milder increases in inflammation/myocardial indices compared to loading-dose atorvastatin.
  • No significant differences in liver function or adverse reaction rates were observed among the groups.

Conclusions:

  • Loading-dose atorvastatin and rosuvastatin are effective and safe for CI treatment.
  • Rosuvastatin shows an advantage in lipid-lowering effects and potentially inflammatory markers.
  • These findings support the use of loading-dose statins, particularly rosuvastatin, in CI management.
Abstract

Keywords:
Loading doseatorvastatincerebral infarctionrosuvastatin

More Related Videos

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability09:11

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Published on: February 23, 2016

21.5K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

14.8K

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
579
Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

Antianginal Drugs: Calcium Channel Blockers and Ranolazine

Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
462
Dose-Response Relationship: Potency and Efficacy01:22

Dose-Response Relationship: Potency and Efficacy

The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
4.3K
Coronary Artery Disease V: Surgical Management01:27

Coronary Artery Disease V: Surgical Management

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
3