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Analysis of relevant influencing factors for recurrent urinary tract infections in children: exploring predictive
Guilin Wang1, Jian Lin1, Jiongxuan Xu1
1Department of Female Urology and Pediatric Surgery, Longyan First Affiliated Hospital of Fujian Medical University, 12th Floor, North Building, Branch of Longyan First Hospital Caoxi Street, Xinluo District, Longyan 364000, Fujian, China.
Insights
Recurrent urinary tract infections (UTIs) in children are linked to anemia, constipation, and urinary system malformations. Urinary system malformations are the strongest predictor of recurrent UTIs in pediatric patients.
Area of Science:
- Pediatrics
- Immunology
- Urology
Background:
- Recurrent urinary tract infections (UTIs) pose a significant health challenge in children, impacting their quality of life and potentially leading to long-term complications.
- Understanding the factors contributing to UTI recurrence is crucial for developing effective prevention and treatment strategies.
Purpose of the Study:
- To identify key factors influencing recurrent UTIs in pediatric patients.
- To explore predictive markers for recurrent UTIs.
- To analyze intervention impacts on quality of life and immunoglobulin levels.
Main Methods:
- A retrospective analysis of 158 children with UTIs was performed, comparing 36 children with recurrent UTIs to 122 without.
- Quality of life (SF-36 scores), immunoglobulin A (IgA), and immunoglobulin G (IgG) levels were assessed.
- Multivariate logistic regression and ROC curve analysis were used to identify risk factors and predictive capabilities.
Main Results:
- Children with recurrent UTIs showed no significant improvement in quality of life post-treatment compared to the non-recurrent group.
- Lower IgA and IgG levels were observed in the recurrent UTI group.
- Anemia, urinary system malformation, constipation, and decreased IgA/IgG levels were identified as independent risk factors for recurrent UTIs.
Conclusions:
- Urinary system malformations, constipation, anemia, and reduced IgA/IgG levels are significant risk factors for recurrent UTIs in children.
- Urinary system malformation demonstrates superior predictive value for recurrent UTIs compared to other identified risk factors.
Objective:
To analyze the factors influencing recurrent urinary tract infections (UTIs) in children and explore predictive factors and intervention measures.
Methods:
Data of 158 children with UTIs treated at the Longyan First Affiliated Hospital of Fujian Medical University from January 2020 to June 2023 were analyzed. Among them, 122 children without recurrent UTIs were included in a non-recurrent group, while the remaining 36 were included in a recurrent group. The quality of life prior to treatment and six weeks after treatment, the immunoglobulin A (IgA) and immunoglobulin G (IgG) levels after treatment, the relationship between the quality of life after six weeks of treatment and the levels of IgA and IgG were analyzed. Multivariate logistic regression analysis was conducted to identify factors impacting the recurrence of UTIs, and receiver operating characteristic (ROC) curves were generated to predict recurrent UTIs based on independent risk factors.
Results:
Before treatment, no notable difference was observed in Short Form 36 Health Survey (SF-36) scores between the non-recurrent group and the recurrent group (P>0.05). After treatment, the SF-36 scores notably increased in the non-recurrent group (P<0.0001), while there was no notable increase in the recurrent group (P>0.05). However, the difference in SF-36 scores after treatment was significant between the two groups (P<0.0001). In addition, there was a significantly positive correlation between IgA levels and quality of life after 6 weeks of treatment (P<0.05). The recurrent group showed significantly lower IgA and IgG levels than the non-recurrent group (P<0.05). Multivariate logistic regression analysis identified anemia, urinary system malformation, constipation, decreased IgA level, and decreased IgG level as independent risk factors for recurrent UTIs in children. ROC curves-based analysis of independent risk factors demonstrated that urinary system malformation had a better performance in predicting recurrent UTIs in children than the other four factors.
Conclusion:
Urinary system malformation, constipation, anemia, decreased IgA and IgG levels are all identified as independent risk factors for recurrent UTIs in children, and urinary system malformation is a better predictor for recurrent UTIs in children than the other four factors.
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