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Does Tranexamic Acid Administration Increase the Risk of Thromboembolism?
Ibrahim Al Babtain1,2, Khalid H Alhadlaq3, Ziad A Aljaafri3
1General Surgery, Ministry of National Guard Health Affairs (MNGHA), Riyadh, SAU.
Cureus
|October 14, 2024
Summary
This study found no significant link between tranexamic acid (TXA) and venous thromboembolism (VTE) risk in trauma patients. Further research is needed to confirm these findings on TXA
Area of Science:
- Trauma Care
- Pharmacology
- Thrombosis Research
Background:
- Hemorrhage following trauma is a leading cause of death globally.
- Venous thromboembolism (VTE) is a frequent complication in hypercoagulable states.
- The association between tranexamic acid (TXA) and VTE risk is debated.
Purpose of the Study:
- To investigate the potential association between TXA administration and VTE development in trauma patients.
- To clarify the controversial link between antifibrinolytic therapy and thrombotic events.
Main Methods:
- Retrospective cohort study of 361 adult trauma patients receiving TXA.
- Data collected from King Abdulaziz Medical City (KAMC) between 2016-2020.
- Evaluation of VTE (DVT or PE) and mortality outcomes post-TXA administration.
Main Results:
- Nine patients (2.5%) developed deep vein thrombosis (DVT), with one fatality.
- Five patients (1.4%) developed pulmonary embolism (PE), with no associated deaths.
- No statistically significant association was found between TXA administration and VTE risk.
Conclusions:
- The risk of VTE associated with TXA in trauma patients remains inconclusive.
- This study did not demonstrate a significant link between TXA and VTE.
- Larger studies are required to definitively establish risk factors for VTE after TXA use in trauma.
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