Myxofibrosarcoma: An Unusual Occurrence in the Extremities and Its Integrated Management in India

Area of Science:

• Oncology
• Surgical Pathology

Background:

• Myxofibrosarcoma (MFS) is a common soft-tissue sarcoma in the elderly, characterized by myxoid and fibrous tissue.
• MFS can present with varying grades of aggression, influencing patient outcomes.

Observation:

• A large (25 x 20 cm²) spindle cell sarcoma with ulceration was observed on the anterior right thigh of a woman in her 50s.
• Computed tomography lower limb angiogram was utilized to assess the vascularity of the tumor.
• The patient underwent wide surgical excision and anterolateral flap reconstruction.

Findings:

• Histopathological analysis confirmed a grade 2 Myxofibrosarcoma.
• The large tumor size posed a significant risk of morbidity and mortality.

Implications:

• Integrated management involving general surgery, vascular surgery, and plastic surgery is crucial for optimal Myxofibrosarcoma treatment.
• This case underscores the importance of multidisciplinary approaches in managing complex soft-tissue sarcomas.