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Trichomoniasis

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Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.

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Updated: Jun 26, 2026

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Published on: May 24, 2011

Characterizing trachoma elimination using serology.

Everlyn Kamau¹, Pearl Anne Ante-Testard¹, Sarah Gwyn²

¹F.I. Proctor Foundation, University of California San Francisco, USA.

Medrxiv : the Preprint Server for Health Sciences

|October 14, 2024

Summary

This summary is machine-generated.

This study introduces a new method to assess Chlamydia trachomatis transmission using antibody measurements in children. It helps determine if trachoma elimination programs need to continue or can be scaled back.

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Area of Science:

Public Health
Infectious Disease Epidemiology
Immunology

Background:

Trachoma elimination is a global health priority by 2030.
Serological IgG antibody measurements in children are being explored for surveillance.
Lack of guidelines for serology application is a challenge in disease elimination.

Purpose of the Study:

To develop a generalizable approach for using serology in trachoma surveillance.
To estimate population-level seroconversion rates (SCR) across varying endemicity levels.
To propose thresholds for SCR to inform program decision-making.

Main Methods:

Collation of Chlamydia trachomatis Pgp3 and CT694 IgG measurements from 63,911 children (ages 1-9) across 48 serosurveys.
Analysis of data from Africa, Latin America, and the Pacific Islands.
Estimation of population-level seroconversion rates (SCR) along a gradient of trachoma endemicity.

Main Results:

A novel, generalizable approach was developed to estimate C. trachomatis transmission probability.
Population-level SCR were estimated across diverse geographic regions and endemicity levels.
Potential thresholds for SCR were identified to guide programmatic action.

Conclusions:

The proposed serological approach can inform trachoma program decision-making.
This method offers a way to assess transmission and guide interventions for elimination.
Serology provides a valuable tool for monitoring progress towards trachoma elimination goals.