Association of Atrial Fibrillation and/or Flutter With Adverse Cardiac Outcomes and Mortality in Patients With Wolff-Parkinson-White Syndrome
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View abstract on PubMed
Summary
This summary is machine-generated.Patients with Wolff-Parkinson-White (WPW) syndrome and atrial fibrillation/flutter (AF/AFL) face increased risks of adverse cardiac events and death. Early screening and ablation may be crucial for this high-risk group.
Area Of Science
- Cardiology
- Electrophysiology
- Public Health
Background
- Wolff-Parkinson-White (WPW) syndrome involves accessory pathways, potentially causing malignant arrhythmias and sudden cardiac death.
- Atrial fibrillation and/or flutter (AF/AFL) are common arrhythmias associated with WPW syndrome.
- The impact of AF/AFL on cardiac outcomes in WPW patients requires further investigation.
Purpose Of The Study
- To determine the effect of AF/AFL on adverse cardiac outcomes and mortality in patients with WPW syndrome.
- To compare cardiac composite outcomes and mortality rates between WPW patients with and without AF/AFL.
- To identify risk factors associated with adverse events in WPW syndrome.
Main Methods
- A retrospective cohort study of Military Health System patients with WPW syndrome (2014-2019).
- Patients were categorized into subgroups based on the presence or absence of AF/AFL.
- Statistical analyses included Kaplan-Meier curves and Cox proportional models to assess outcomes and mortality.
Main Results
- The study included 35,539 WPW patients; 14.9% had AF/AFL.
- Incidence rates for composite cardiac outcomes and mortality were significantly higher in the AF/AFL subgroup (8.18 vs 4.90 and 4.09 vs 2.13 per 100 person-years, respectively; P < .001).
- Adjusted analyses revealed that AF/AFL was associated with a 12% higher risk of composite outcomes and a 16% higher risk of mortality.
Conclusions
- WPW syndrome patients with AF/AFL exhibit a greater association with adverse cardiac events and mortality.
- More aggressive electrophysiology screening and ablation strategies may be beneficial for WPW patients with AF/AFL.
- This finding underscores the importance of risk stratification and timely intervention in WPW syndrome management.
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