Related Experiment Video

Updated: Jun 10, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

8.6K

G protein coupled receptor in apoptosis and apoptotic cell clearance

Xinyan Li1, Chao Li1, Yang Kang1

  • 1College of Life Sciences, Shaanxi Normal University Xi'an China.

FASEB Bioadvances
|October 14, 2024
PubMed

Insights

Efficient clearance of apoptotic cells is vital for health. G protein-coupled receptors (GPCRs) play a key role in this process, offering potential therapeutic targets for diseases linked to impaired cell death removal.

Area of Science:

  • Cell biology
  • Molecular biology
  • Immunology

Background:

  • Apoptosis, or programmed cell death, is essential for homeostasis.
  • Failure in apoptotic cell clearance is linked to diseases like lupus, Alzheimer's, atherosclerosis, and cancer.
  • G protein-coupled receptors (GPCRs) are a large family of membrane receptors involved in cellular signaling.

Purpose of the Study:

  • To investigate the role of GPCRs in the process of apoptotic cell clearance.
  • To explore the potential of GPCRs as therapeutic targets for diseases associated with failed apoptotic cell removal.

Main Methods:

  • Literature review of studies on GPCRs and apoptosis.
  • Analysis of signaling pathways involving GPCRs in cell death and clearance.
  • Identification of GPCRs implicated in apoptotic cell recognition, phagocytosis, and degradation.

Main Results:

  • Numerous GPCRs are involved in both apoptosis signaling and the clearance of apoptotic cells.
  • GPCRs modulate key steps in apoptotic cell removal, including recognition and phagocytosis.
  • Specific GPCRs have been identified as critical players in maintaining cellular homeostasis through apoptotic cell clearance.

Conclusions:

  • GPCRs are integral components of the apoptotic cell clearance machinery.
  • Understanding GPCR mechanisms in apoptotic cell removal is crucial for developing novel therapeutics.
  • Targeting GPCRs may offer new strategies for treating diseases linked to impaired apoptotic cell clearance.
Keywords:
G proteinGPCRsapoptosisapoptotic cell clearancesignal transduction

More Related Videos

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.0K
Detection and Isolation of Apoptotic Bodies to High Purity12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

10.6K

Related Concept Videos

The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.3K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.4K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
8.3K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
3.7K
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
11.2K
Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
12.3K