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Anti-Myelin-Associated Glycoprotein Neuropathy: Recent Developments
Jennifer Morganroth1, Chafic Karam1
1Department of Neurology, University of Pennsylvania.
Background:
The purpose of this review is to give an update on myelin-associated glycoprotein (MAG) neuropathy.
Recent Findings:
There are several recent developments in anti-MAG neuropathy, with the major one being the retrospective analysis of 50 clinical trials that showed that at least a 50% reduction in anti-MAG levels is associated with a therapeutic response. Other updates address antibody levels needed for a positive test, response, and exacerbations to therapy and the type of antibody more associated with malignancy.
Implications For Practice:
Anti-MAG neuropathy is heterogeneous, and the natural history of the disease continues to be refined. Treatment options are being explored for refractory disease.
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