Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dental caries vaccine: some problems solved?

D L Everhart1, C P Mallett, G Doyle

  • 1Department of Microbiology, New York University Dental Center, New York 10010.

Microbiological Sciences
|October 1, 1985
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: A cross-sectional study of the relative availability and prominence of shelf space allocated to healthy and unhealthy foods in supermarkets in urban Ireland, by area-level deprivation.

BMC public health·2024
Same author

A cross-sectional study of the relative availability and prominence of shelf space allocated to healthy and unhealthy foods in supermarkets in urban Ireland, by area-level deprivation.

BMC public health·2024
Same author

Supermarket availability and socio-economic deprivation in urban Ireland - CORRIGENDUM.

The Proceedings of the Nutrition Society·2022
Same author

Self-rated health literacy is associated with exercise frequency among adults aged 50+ in Ireland.

European journal of public health·2017
Same author

Recent trends in breast, cervical, and colorectal cancer screening test utilization in Canada, using self-reported data from 2008 and 2012.

Current oncology (Toronto, Ont.)·2015
Same author

The effects of altered distances between obstacles on the jump kinematics and apparent joint angulations of large agility dogs.

Veterinary journal (London, England : 1997)·2015
Same journal

Fungal cell wall synthesis: the construction of a biological structure.

Microbiological sciences·1988
Same journal

Microbial digestion of hemicelluloses in the rumen.

Microbiological sciences·1988
Same journal

Assessing the risks of releasing recombinant Streptomyces in soil.

Microbiological sciences·1988
Same journal

Outbreaks of listeriosis/Listeria-contaminated foods.

Microbiological sciences·1988
Same journal

Virus-induced diseases of the eye: the role of herpesviruses in retinitis.

Microbiological sciences·1988
Same journal

Epstein-Barr virus and the chronic fatigue syndrome: a short review.

Microbiological sciences·1988
See all related articles

Developing a dental caries vaccine faces challenges with Streptococcus mutans, including potential heart-reactive antibodies and the need for broad serotype protection. This research explores solutions to these immunogen-related issues.

Area of Science:

  • * Dentistry
  • * Immunology
  • * Vaccinology

Background:

  • * Dental caries remains a significant global oral health concern.
  • * Streptococcus mutans is a primary etiological agent of dental caries.
  • * Previous vaccine development efforts using S. mutans have encountered specific obstacles.

Purpose of the Study:

  • * To review and discuss potential solutions to challenges in developing a dental caries vaccine.
  • * To address the issues of heart-reactive antibodies and serotype diversity associated with S. mutans immunogens.
  • * To explore strategies for overcoming limitations in S. mutans-based vaccine candidates.

Main Methods:

  • * Literature review and synthesis of existing research on dental caries vaccines.
  • * Analysis of immunological responses to Streptococcus mutans.

Related Experiment Videos

  • * Discussion of potential vaccine strategies and modifications.

    • Main Results:

    • * Identified two key problems with using Streptococcus mutans as an immunogen: production of heart-reactive antibodies and the necessity of covering multiple serotypes.
    • * Explored potential strategies to mitigate these identified risks.
    • * Highlighted the complexity of developing a broadly protective and safe dental caries vaccine.

    Conclusions:

    • * Overcoming the challenges of immunogenicity and serotype specificity is crucial for successful dental caries vaccine development.
    • * Further research is needed to refine S. mutans-based vaccine approaches or explore alternative strategies.
    • * The development of an effective dental caries vaccine holds significant promise for public oral health.