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Updated: Jul 25, 2026
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
Histopathological and immunohistochemical analysis of a suspected extraskeletal osteosarcoma in a rabbit (Oryctolagus
Julia Penna de Andrade1, Camilla Faria Soares1, André Luiz de Moura Junqueira2
1Veterinarian, Resident. Programa de Residência em Saúde Única com Ênfase em Interface Saúde Humana e Silvestre- Escola de Veterinária da Universidade Federal de Minas Gerais (UFMG). Pampulha, Belo Horizonte, MG, Brazil.
Abstract:
An 8-year-old male rabbit (Oryctolagus cuniculus) presented with a subcutaneous mass in the proximal region of the fourth and accessory digit measuring 5.5 x 3.5 x 5.2cm. The mass was non-alopecic and exhibited irregular surface, ulceration and necrosis with predominantly pale and light brown coloring. Radiography revealed no involvement of bone and adjacent periosteum. The mass was marginally resected and the electrochemotherapy (ECT) was performed on the surgical bed. Histopathology and immunohistochemical analysis revealed positive reactions for Vimentin, Runx-2 and ki-67, leading to a diagnosis of extraskeletal osteosarcoma (ESOS). This report described a case of ESOS in a rabbit, thereby delineating its clinical presentation, anatomopathological characteristics, diagnostic modalities and recommended therapeutic interventions.
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