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Published on: February 23, 2014
[Meningitis and myelitis by hypervirulent Klebsiella pneumoniae]
María Vanesa Durán1, María Fernanda Landaburu1, Mariana Scarabino2
1Unidad de Infectología, Sanatorio Dr. Julio Méndez, Buenos Aires, Argentina.
Abstract:
Invasive liver abscess syndrome caused by hypervirulent Klebsiella. pneumoniae is a rare disease. This type of K. pneumoniae is aggressive and invasive, despite its sensitivity profile. We report the case of a 62-year-old man with diabetes mellitus, who was admitted to our hospital with meningeal syndrome. Within 24 hours of admission, Gram negative bacilli were isolated blood and cerebrospinal fluid cultures, which were later identified as K. pneumoniae. Liver abscess was detected by computed tomography. Despite early antibiotic treatment, the patient developed back pain that prevented him from moving and right hemiparesis. Increased signal from the central region of the spinal medulla compatible with myelitis was identified by magnetic resonance, for which he received methylprednisolone 1 g/day for 5 days. The patient evolved favorably. Infections caused by hypermucoviscous K. pneumoniae are aggressive and invasive, and more common in men with a history of diabetes mellitus, as in this case. These infections require early antibiotic treatment and the search of metastatic infections.
Insights
Hypervirulent Klebsiella pneumoniae causes rare, aggressive invasive liver abscess syndrome. Early diagnosis and treatment are crucial for managing this invasive infection, especially in diabetic men.
Area of Science:
- Infectious Diseases
- Microbiology
- Neurology
Background:
- Invasive liver abscess syndrome is a rare but severe condition.
- Hypervirulent Klebsiella pneumoniae strains are known for their aggressive and invasive nature.
Observation:
- A 62-year-old male with diabetes presented with meningeal syndrome.
- Klebsiella pneumoniae was identified in blood and cerebrospinal fluid cultures within 24 hours.
- Computed tomography revealed a liver abscess, and magnetic resonance imaging showed myelitis.
Findings:
- Despite early antibiotic therapy, the patient developed neurological complications including myelitis.
- Treatment with methylprednisolone led to a favorable clinical outcome.
- Infections by hypermucoviscous K. pneumoniae are aggressive, invasive, and more prevalent in diabetic men.
Implications:
- Prompt antibiotic treatment is essential for invasive K. pneumoniae infections.
- Metastatic infections should be actively investigated in patients with hypervirulent K. pneumoniae.
- This case highlights the aggressive potential of K. pneumoniae and the importance of considering neurological involvement.
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