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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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36
[Thorns in hands, think in spiny keratoderma].
Debora Pellegrini1, Daniel Padilla Salcedo1, Gabriel Noriega2
1Servicio de Clínica Médica, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.
Medicina
|October 14, 2024
Summary
Spiny keratoderma, a rare skin condition, may indicate underlying cancer. A patient
Area of Science:
- Dermatology
- Hepatology
- Oncology
Background:
- Spiny keratoderma is a rare dermatological condition characterized by hyperkeratotic palmoplantar lesions.
- It can be inherited or sporadic, with sporadic cases sometimes linked to chronic diseases or neoplasms.
Observation:
- A case study of a man in his seventh decade presenting with palmar spiny keratoderma.
- The patient had cirrhosis due to primary sclerosing cholangitis and hepatocellular carcinoma.
Findings:
- The patient's spiny keratoderma resolved two months post-liver transplant.
- This remission suggests a paraneoplastic link between the skin condition and hepatocellular carcinoma.
Implications:
- Spiny keratoderma may serve as a paraneoplastic marker for hepatocellular carcinoma.
- This case highlights the importance of investigating underlying malignancies in patients with sporadic spiny keratoderma.
- The report is the first of its kind from Argentina, expanding the literature on this rare manifestation.
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