Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Present status of antimycotics.

D Kerridge1

  • 1Department of Biochemistry, University of Cambridge, UK.

Microbiological Sciences
|January 1, 1985
PubMed
Summary
This summary is machine-generated.

This study reviews four main classes of antifungal drugs: polyene macrolide antibiotics, synthetic imidazoles, griseofulvin, and 5-fluorocytosine. While the action of 5-fluorocytosine is clear, the molecular mechanisms of the others require further research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

5-Fluorocytosine antagonizes the action of sterol biosynthesis inhibitors in Candida glabrata.

The Journal of antimicrobial chemotherapy·1999
Same author

The effect of antifungal drugs in combination on the growth of Candida glabrata in solid and liquid media.

The Journal of antimicrobial chemotherapy·1998
Same author

Manometric rhinometry.

Clinical otolaryngology and allied sciences·1995
Same author

Manometric rhinometry: a new method of measuring nasal volume.

Rhinology·1995
Same author

A purine permease in Candida glabrata.

FEMS microbiology letters·1995
Same author

Characterisation of a partially purified uracil phosphoribosyltransferase from the opportunistic pathogen Candida albicans.

Mycopathologia·1994
Same journal

Fungal cell wall synthesis: the construction of a biological structure.

Microbiological sciences·1988
Same journal

Microbial digestion of hemicelluloses in the rumen.

Microbiological sciences·1988
Same journal

Assessing the risks of releasing recombinant Streptomyces in soil.

Microbiological sciences·1988
Same journal

Outbreaks of listeriosis/Listeria-contaminated foods.

Microbiological sciences·1988
Same journal

Virus-induced diseases of the eye: the role of herpesviruses in retinitis.

Microbiological sciences·1988
Same journal

Epstein-Barr virus and the chronic fatigue syndrome: a short review.

Microbiological sciences·1988
See all related articles

Area of Science:

  • Pharmacology
  • Mycology
  • Medicinal Chemistry

Background:

  • Antifungal drug discovery is crucial for treating fungal infections.
  • Four primary classes of antimycotic agents are clinically utilized.
  • Understanding drug mechanisms is key to improving treatments.

Purpose of the Study:

  • To outline the principal classes of antifungal drugs.
  • To describe the known mechanisms of action for these drug classes.
  • To highlight areas where further research into molecular mechanisms is needed.

Main Methods:

  • Literature review of established antimycotic drug classes.
  • Summary of current understanding of drug interactions with fungal cells.
  • Identification of knowledge gaps in drug mechanism elucidation.

Related Experiment Videos

Main Results:

  • Polyene macrolide antibiotics and synthetic imidazoles target fungal cell membranes.
  • Griseofulvin and 5-fluorocytosine affect nuclear metabolism.
  • The precise molecular actions of polyenes, imidazoles, and griseofulvin remain incompletely understood.

Conclusions:

  • Antifungal drugs exhibit diverse mechanisms of action, targeting either cell membranes or nuclear metabolism.
  • Further investigation into the molecular intricacies of polyene macrolides, imidazoles, and griseofulvin is warranted.
  • Elucidating these mechanisms could lead to the development of more effective antifungal therapies.