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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
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Lipid-based Nanoparticles as Drug Delivery System for Modern Therapeutics
Shivani Gandhi1, Divyesh Harshadkumar Shastri1
1Department of Pharmaceutics and Pharmaceutical Technology, K.B. Institute of Pharmaceutical Education and Research, A Constituent College of Kadi Sarva Vishwavidyalaya, Sarva Vidyalaya Kelavani Mandal (SVKM), Gh-6, Sector-23, Kadi Campus, Gandhinagar, Gujarat, 382016, India.
Pharmaceutical Nanotechnology
|October 14, 2024
Summary
Lipid-based nanoparticles offer advanced drug delivery solutions, overcoming biological barriers and enhancing therapeutic efficacy. Ongoing research addresses formulation and stability challenges for broader clinical application.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Lipid-based nanoparticulate systems are revolutionizing drug delivery.
- These systems include liposomes, lipid nanoparticles, and solid lipid nanoparticles.
- Lipids offer biocompatibility and biodegradability for therapeutic encapsulation.
Purpose of the Study:
- To review advancements in lipid-based nanoparticulate drug delivery.
- To identify challenges and future potential in modern therapeutics.
- To highlight the role of these systems in overcoming drug delivery obstacles.
Main Methods:
- Comprehensive literature review of lipid-based nanoparticulate systems.
- Analysis of their application in various therapeutic areas.
- Evaluation of their potential in crossing biological barriers.
Main Results:
- Lipid nanoparticles enhance drug solubility, bioavailability, and enable controlled/targeted delivery.
- They successfully overcome biological barriers like the blood-brain barrier and mucosal barriers.
- Biocompatibility and reduced toxicity are key advantages, supporting personalized medicine.
Conclusions:
- Lipid-based nanoparticles represent a significant platform for advanced drug delivery.
- Further innovation is needed to address formulation, stability, and regulatory hurdles.
- These systems hold immense promise for future therapeutic interventions.
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