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Updated: Jun 10, 2025

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Published on: July 9, 2016
Psychiatry and sensation: the epigenetic links
Madia Lozupone1, Ivana Leccisotti2, Mario Altamura2
1Department of Translational Biomedicine & Neuroscience "DiBraiN", University of Bari Aldo Moro, Bari, 70124, Italy.
None:
A complex interaction among sensory, social and epigenetic determinants in psychiatric conditions was described across all age strata. The high prevalence of mental disorders in individuals with sensory deficits might be attributed to the interaction among social isolation, cognitive functioning and sensory processing. The epigenetic implications of such interactions were examined: environmental and social factors can affect gene expression and impact the pathogenesis of psychiatric disorders also through sensory processing. This article discussed the role of social determinants, in other words, social isolation, loneliness and chronic stress, in promoting psychiatric disorders and, in a vicious circle, sensory deficits (vision, hearing, olfaction and somatosensation). We emphasized the importance of integrating social, sensory and epigenetic factors to target different treatments for psychiatric conditions.
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