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Green Synthesis of Quinoline-Based Ionic Liquid.

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Antimicrobial resistance (AMR) is a growing threat. Researchers developed a novel quinoline-based ionic liquid (IL) using green synthesis, showing significant antimicrobial activity with low toxicity.

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Area of Science:

  • Green Chemistry
  • Medicinal Chemistry
  • Biotechnology

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat, reducing the efficacy of conventional antibiotics.
  • Ionic Liquids (ILs) are emerging as promising eco-friendly alternatives due to their stability, low volatility, and unique properties.
  • ILs have demonstrated potential in biomedical applications, including protein stabilization and enzyme activity enhancement.

Purpose of the Study:

  • To present the green synthesis and characterization of a novel quinoline-based ionic liquid.
  • To evaluate the antimicrobial potency and cytotoxicity of the synthesized ionic liquid.
  • To explore the potential of this ionic liquid as an artificial chaperone.

Main Methods:

  • One-pot synthesis under solvent-free, greener reaction conditions.
  • Characterization using 1H Nuclear Magnetic Resonance (NMR), 13C NMR, and Infrared (IR) spectroscopy.
  • Validation of biological potential through Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis and disc diffusion assay.

Main Results:

  • Successful green synthesis of a quinoline-based ionic liquid with enhanced efficiency and yield.
  • The synthesized IL exhibited significant antimicrobial potency.
  • The compound demonstrated low cytotoxicity and notable artificial chaperone activity.

Conclusions:

  • The developed quinoline-based IL is a potent antimicrobial agent with favorable safety and chaperone properties.
  • Green synthesis approaches are effective for producing novel antimicrobial compounds.
  • This IL holds promise for combating antimicrobial resistance and advancing biomedical applications.