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A Cell Free Assay to Study Chromatin Decondensation at the End of Mitosis
Published on: December 19, 2015
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How condensed are mitotic chromosomes?
Hide A Konishi1, Hironori Funabiki1
1Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY, USA.
The Journal of Cell Biology
|October 14, 2024
Abstract:
Chromosomes undergo dramatic compaction during mitosis, but accurately measuring their volume has been challenging. Employing serial block face scanning electron microscopy, Cisneros-Soberanis et al. (https://doi.org/10.1083/jcb.202403165) report that mitotic chromosomes compact to a nucleosome concentration of ∼760 µM.
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