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Assessing the Correlation Between Retinal Arteriolar Bifurcation Parameters and Coronary Atherosclerosis
Guangzheng Dai1, Geng Wang2, Sile Yu3
1Dragonfleye Healthcare Technology LLC, Shenyang, Liaoning, China.
Retinal arteriolar bifurcations show altered morphology in severe coronary artery disease (CAD). These changes in bifurcation angles may indicate disease severity, offering a potential new diagnostic marker.
Area of Science:
- Ophthalmology
- Cardiology
- Medical Imaging
Background:
- Coronary artery disease (CAD) is a leading cause of mortality worldwide.
- Retinal microvasculature changes can reflect systemic vascular health.
- Investigating retinal arteriolar bifurcations offers insights into CAD.
Purpose of the Study:
- To investigate the relationship between retinal arteriolar bifurcation morphology and coronary artery disease (CAD).
- To determine if specific bifurcation parameters correlate with CAD severity.
Main Methods:
- Cross-sectional observational study of 444 participants.
- Fundus photography to analyze 9625 retinal arteriolar bifurcations.
- Measured vessel diameters, bifurcation angles, and compared to theoretical optimal angles.
Main Results:
- Significant deviations in bifurcation angles were observed in severe CAD patients compared to moderate CAD patients.
- Specifically, a decrease in one angle and an increase in another were noted.
- Adjustments were made for asymmetry ratio, area ratio, and optic disc distance.
Conclusions:
- Retinal arteriolar bifurcation morphology is altered in patients with severe CAD.
- These morphological changes may serve as a potential indicator of CAD severity.
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