Related Experiment Video

Updated: Jun 10, 2025

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

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Exosomal microRNA as a key regulator of PI3K/AKT pathways in human tumors

Saade Abdalkareem Jasim1,2, Abdulrahman T Ahmed3, Aziz Kubaev4

  • 1Medical Laboratory Techniques Department, Al-Maarif University College, Ramadi, Anbar, Iraq.

Medical Oncology (Northwood, London, England)
|October 14, 2024
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are key in the PI3K/AKT pathway, influencing cancer. Exosomal miRNAs modulate this axis, impacting cancer progression and drug resistance.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression by targeting mRNA.
  • The PI3K/AKT pathway is crucial for cellular functions and its aberrant activation is linked to cancer progression.
  • Exosomes contain miRNAs that can influence cellular activities and cancer development.

Purpose of the Study:

  • To provide an overview of the PI3K/AKT pathway and exosomal miRNA roles in cancer.
  • To explore the function and medical applications of the exosomal miRNA/AKT/PI3K axis in cancer biology.

Main Methods:

  • Literature review of recent research on miRNAs, the PI3K/AKT pathway, and exosomes in cancer.
  • Analysis of the regulatory mechanisms of exosomal miRNAs on the PI3K/AKT pathway.
  • Synthesis of information on the implications for cancer progression and drug resistance.

Main Results:

  • MiRNAs are concentrated in the PI3K/AKT pathway, affecting gene expression.
  • Exosomal miRNAs can modulate the PI3K/AKT pathway, influencing cancer cell behavior.
  • The exosomal miRNA/AKT/PI3K axis is implicated in cancer progression and drug resistance.

Conclusions:

  • The PI3K/AKT pathway is a critical regulator of cellular functions and cancer.
  • Exosomal miRNAs play a significant role in cancer by modulating the PI3K/AKT pathway.
  • Targeting the exosomal miRNA/AKT/PI3K axis holds potential for cancer therapy and overcoming drug resistance.
Keywords:
AKTCancerExosomePI3KmiRNA

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