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Related Concept Videos

Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

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The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
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Related Experiment Video

Updated: Jun 10, 2025

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
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Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology

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Age-Related Changes in Heart Rate Variability from the Neonatal Period to Adulthood.

A A Grinevich1, N K Chemeris2

  • 1Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia. grin_aa@mail.ru.

Doklady. Biochemistry and Biophysics
|October 14, 2024
PubMed
Summary

This study reveals how heart rate variability (HRV) regulation changes with age in healthy individuals. Key autonomic and humoral control mechanisms show distinct patterns from infancy through adulthood.

Keywords:
Hilbert–Huang methodage-related dynamicscardiovascular systemheart rate variabilitywavelet analysis

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Area of Science:

  • Physiology
  • Cardiology
  • Biomedical Engineering

Background:

  • Heart rate variability (HRV) reflects autonomic nervous system function.
  • Understanding age-related changes in HRV is crucial for assessing cardiovascular health.
  • Previous studies have not fully characterized the frequency-dependent regulation of HRV across the lifespan.

Purpose of the Study:

  • To investigate the age-related dynamics of frequency-dependent heart rate variability regulation.
  • To analyze Holter ECG recordings from healthy neonates, infants, adolescents, and adults.
  • To identify specific patterns in HRV spectral composition and regulatory mechanisms across different age groups.

Main Methods:

  • Analysis of Holter ECG recordings from four age groups: neonates, one-year-old infants, adolescents, and adults.
  • Application of Hilbert-Huang transform to analyze HRV spectral composition into nine modes.
  • Quantification of central frequencies and amplitudes of HRV modes.

Main Results:

  • A wide spectral composition of HRV was identified, comprising nine Hilbert-Huang modes (0.0001–2 Hz).
  • Central frequencies of HRV modes decreased postnatally, stabilizing in adolescence.
  • Systemic humoral regulation showed increased amplitudes, plateauing in adolescence.
  • Autonomic control-associated modes exhibited a dome-shaped age-related change, peaking in adolescence.

Conclusions:

  • Age-related changes in HRV parameters are consolidated and quantitatively demonstrable from neonates to adulthood.
  • Distinct developmental trajectories exist for frequency-dependent HRV regulation, influenced by autonomic and humoral systems.
  • Adolescence represents a key period for the maturation and stabilization of certain HRV regulatory mechanisms.