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Bridging Data Models in Health Care With a Novel Intermediate Query Format for Feasibility Queries: Mixed Methods

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Summary
This summary is machine-generated.

Researchers can now more easily query clinical data availability using the new Clinical Cohort Definition Language (CCDL). This standardized syntax simplifies data access across institutions, advancing health research.

Keywords:
CQLFHIRJSONclinical researchcohort definitiondevelopdevelopmenteligibility criteriafeasibilityhealthcare interoperabilityimplementationinformaticsintermediate query formatinteroperabilityinteroperableontologiesontologyportalportalsqueriesquery

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Area of Science:

  • Health Informatics
  • Clinical Data Management
  • Biomedical Research

Background:

  • Advancing clinical research requires fast and easy access to diverse data sources.
  • The German Medical Informatics Initiative (MII) uses the Fast Healthcare Interoperability Resources (FHIR) standard for data harmonization.
  • Querying data across different systems and standards (e.g., CQL, FHIR Search) presents significant challenges.

Purpose of the Study:

  • To develop and implement an intermediate query syntax for feasibility queries.
  • To simplify data availability assessments for researchers.
  • To enhance interoperability within the federated German health research portal (Forschungsdatenportal Gesundheit) and the MII.

Main Methods:

  • Analysis of requirements for feasibility queries and existing tools.
  • Development of an intermediate query syntax translatable to various repository-specific languages.
  • Definition of a JSON schema and ontology for the new syntax.

Main Results:

  • The Clinical Cohort Definition Language (CCDL) was created for feasibility queries.
  • CCDL combines inclusion/exclusion criteria with filters for time and numerical restrictions.
  • Demonstrated CCDL's translatability and usability across multiple studies and real-world use cases.

Conclusions:

  • A structured query syntax (CCDL) for feasibility queries was developed and evaluated.
  • CCDL was successfully integrated into a research platform across 39 German university hospitals.
  • The new syntax simplifies data access and improves interoperability for clinical research.