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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

Injectable self-assembling peptide hydrogel as a promising vitreous substitute.

Yuting Cai¹, Yatong Xiang², Huilei Dong²

¹Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, PR China.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|October 14, 2024

Summary

A novel negatively charged peptide hydrogel, 3E-OX, shows promise as a vitreous substitute, matching native vitreous properties and demonstrating safety in animal studies for vision restoration.

Keywords:

Biocompatibility Optical coherence tomography Peptide hydrogel Self-assembly Vitreous substitute

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Published on: September 6, 2024

Area of Science:

Biomaterials Science
Ophthalmology
Regenerative Medicine

Background:

Vitreoretinal diseases threaten vision, necessitating vitreous humor replacement after vitrectomy.
Current vitreous substitutes have limitations impacting patient outcomes.
Peptide-based supramolecular hydrogels offer superior optical and biocompatibility properties.

Purpose of the Study:

To design and assess peptide hydrogels (3K-OX and 3E-OX) as potential vitreous humor substitutes.
To compare the physicochemical properties of these hydrogels with native vitreous.
To evaluate the biocompatibility and safety of the most promising candidate.

Main Methods:

Synthesis and characterization of two peptide hydrogels: 3K-OX (positive charge) and 3E-OX (negative charge).
In vitro assessment of optical clarity, refractive index, molecular permeability, and biocompatibility.
In vivo safety and biocompatibility evaluation in animal models.
Application of optical coherence tomography for retinal microvascular assessment.

Main Results:

The negatively charged 3E-OX hydrogel exhibited physicochemical properties closely matching the native vitreous body.
3E-OX demonstrated optimal light transmittance, refractive index, molecular permeability, and biocompatibility in vitro.
Animal studies confirmed the safety and biocompatibility of 3E-OX as a vitreous substitute.
Optical coherence tomography proved effective for evaluating intraocular tamponade materials.

Conclusions:

The negatively charged peptide hydrogel 3E-OX is a highly promising candidate for vitreous humor substitution.
3E-OX offers advantages over existing substitutes due to its biomimetic properties and safety profile.
This study introduces a novel OCT-based method for evaluating vitreous substitutes and advances hydrogel design for ocular applications.