Population-based long-term prognosis analysis of subcutaneous gastrointestinal stromal tumors

Luojie Liu ¹, Xinyu Shao ²

⁰Department of Gastroenterology, Changshu Hospital Affiliated to Soochow University, Suzhou, China.

Surgical Endoscopy +

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October 14, 2024

View abstract on PubMed

Summary

Subcutaneous gastrointestinal stromal tumors (scGISTs) have a worse prognosis than typical GISTs. However, surgery significantly improves survival outcomes for scGIST patients.

Area Of Science

Oncology
Gastrointestinal Surgery
Cancer Epidemiology

Background

Subcutaneous gastrointestinal stromal tumors (scGISTs) are exceptionally rare.
Long-term prognosis data for scGISTs is largely unreported.
This study analyzes the long-term prognosis of scGIST patients.

Purpose Of The Study

To evaluate the long-term survival outcomes of patients with scGISTs.
To compare the prognosis of scGISTs with conventional GISTs.
To identify factors influencing scGIST prognosis.

Main Methods

Utilized the Surveillance, Epidemiology, and End Results (SEER) database (2000-2019).
Employed multiple imputation for missing data.
Conducted Kaplan-Meier analysis and Cox proportional hazards models for overall survival (OS) and cancer-specific survival (CSS).

Main Results

scGIST patients (n=246) showed significantly inferior OS and CSS compared to GIST patients (n=12,636).
Poorer outcomes for scGISTs were consistent across subgroups (age, sex, surgery, chemotherapy).
Surgical intervention in scGIST patients significantly improved 5-year OS (62.1% vs. 30.9%) and CSS (67.8% vs. 40.0%).

Conclusions

scGIST patients face a less favorable prognosis than typical GIST patients.
Surgical intervention is a key factor in improving scGIST patient outcomes.
Age, surgical status, and mitotic rate are significant prognostic factors for scGISTs.

Keywords:

Cancer-specific survival Overall survival SEER Subcutaneous gastrointestinal stromal tumors