AVR/I/SSAPDB: a comprehensive & specialised knowledgebase of antimicrobial peptides to combat VRSA, VISA, and VSSA
Rajat Kumar Mondal1, Debayan Karmakar1, Oshin Pal1
1Biochemistry and Bioinformatics Laboratory, Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, (IIIT-A), Devghat, Jhalwa, Prayagraj, Uttar Pradesh, 211012, India.
Abstract:
The rise of multi-drug resistant (MDR) bacteria, especially strains of Staphylococcus aureus like Vancomycin-resistant S. aureus (VRSA), Vancomycin-intermediate S. aureus (VISA), and Vancomycin-susceptible S. aureus (VSSA), poses a severe threat to global health. This situation underscores the urgent need for novel antimicrobial agents to combat these resistant strains effectively. Here, we are introducing the Anti-Vancomycin-Resistant/Intermediate/Susceptible Staphylococcus aureus Peptide Database (AVR/I/SSAPDB), a manually curated comprehensive and specialised knowledgebase dedicated to antimicrobial peptides (AMPs) that target VRSA, VISA, and VSSA with clinical and non-clinical significance. Our database sources data from PubMed, cataloging 491 experimentally validated AMPs with detailed annotations on peptides, activity, and cross-references to external databases like PubMed, UniProt, PDB, and DrugBank. AVR/I/SSAPDB offers a user-friendly interface with simple to advanced and list-based search capabilities, enabling researchers to explore AMPs against VRSA, VISA, and VSSA. We are hoping that this resource will be helpful to the scientific community in developing targeted peptide-based therapeutics, providing a crucial tool for combating VRSA, VISA, and VSSA, and addressing a major public health concern. AVR/I/SSAPDB is freely accessible via any web-browser at URL: https://bblserver.org.in/avrissa/ .
Insights
A new database, AVR/I/SSAPDB, catalogs 491 antimicrobial peptides targeting Vancomycin-resistant Staphylococcus aureus (VRSA), Vancomycin-intermediate S. aureus (VISA), and Vancomycin-susceptible S. aureus (VSSA). This resource aids in developing new peptide-based therapeutics against these dangerous bacteria.
Area of Science:
- Microbiology
- Biotechnology
- Drug Discovery
Background:
- Multi-drug resistant bacteria, particularly Staphylococcus aureus strains like VRSA, VISA, and VSSA, present a significant global health challenge.
- The emergence of resistance necessitates the development of novel antimicrobial agents.
Purpose of the Study:
- To introduce the Anti-Vancomycin-Resistant/Intermediate/Susceptible Staphylococcus aureus Peptide Database (AVR/I/SSAPDB).
- To provide a specialized, manually curated knowledgebase of antimicrobial peptides (AMPs) effective against VRSA, VISA, and VSSA.
Main Methods:
- Data was collected from PubMed and curated manually.
- The database includes 491 experimentally validated AMPs with detailed annotations.
- Cross-references to external databases such as PubMed, UniProt, PDB, and DrugBank are provided.
Main Results:
- The AVR/I/SSAPDB contains comprehensive information on AMPs targeting specific Staphylococcus aureus strains.
- It offers a user-friendly interface with various search functionalities for researchers.
Conclusions:
- The AVR/I/SSAPDB serves as a valuable resource for the scientific community.
- It aims to facilitate the development of targeted peptide-based therapeutics to combat resistant Staphylococcus aureus strains and address public health concerns.
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