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In Vivo Feasibility of Arterial Embolization with a New Permanent Agar-agar-Based Agent
Thibault Agripnidis1,2,3, Alexis Ruimy4,5,6, Julien Panneau4,5,6
1Interventional Radiology Section, Department of Medical Imaging, University Hospital Timone, AP-HM, 264 Rue Saint-Pierre, 13005, Marseille, France. thibault.agripnidis@ap-hm.fr.
Purpose:
Evaluate the safety and efficacy of an eco-friendly permanent agar-agar-based embolization agent (ABEA) (EmboBio®) for intra-arterial use.
Materials And Methods:
Six pigs embolized with one ABEA torpedo (6 lower polar renal and 6 lumbar arteries) and one coil (6 lower polar renal and 6 lumbar arteries). Technical success was defined as a complete occlusion with no residual flow in DSA. Short-term endpoints included safety (non-targeted embolization), ease of use (embolization preparation time, occlusion time), and DSA controls at day 7, month 1, and month 3. Tissue reaction was assessed via [18F]-FDG PET/CT at month 2 and histological study at month 3.
Results:
ABEA torpedoes achieved immediate and persistent occlusion at month 3 for all kidney and lumbar embolizations (n = 12/12). Control coils had technical success for 12/12, with a persistent occlusion at month 3 for 2/12. No off-target embolization occurred. ABEA torpedoes demonstrate faster occlusion (ABEA: 6 ± 4 s; coils: 427 ± 469 s; p = 0.0022, n = 12) and preparation times (ABEA: 96.9 1 ± 23 s; coils: 150.33 ± 58 s; p = 0.0432, n = 12) after device placement than coil. No significant difference in inflammation between ABEA and coil groups at month 2 (ABEA: 3.35e-6 ± 1.7e-6%ID/mm3; coils: 2.24e-6 ± 8.5e-7%ID/mm3; p = 0.5) on PET imaging. These results were confirmed by histological analysis at month 3.
Conclusion:
Permanent dry foam torpedo comprising agar-agar is effective for arterial embolization. In animal model, one ABEA torpedo demonstrates a faster and more persistent occlusion than one fiber coil.
Levels Of Evidence:
Not applicable.
